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Active substance: 20.205 mg edoxaban tosylate equivalent to 15 mg edoxaban each tablet
Excipients: Mannitol, pregelatinized corn starch, crospovidone,
hydroxypropyl cellulose, magnesium stearate, hypromellose (E464), titanium dioxide
(E171), macrogol 8000, yellow iron oxide (E172), red iron oxide (E172), talc, pure
water carnauba wax
1. What is Lixiana and what is it used for?
Lixiana contains edoxaban as an active ingredient and anticoagulants, blood thinners.
It belongs to a group of drugs, also known as substances. This drug is important for blood clotting.
It prevents the formation of blood clots by preventing factor Xa, a substance.
Lixiana in adults:
Irregular heartbeat called non-valvular atrial fibrillation and at least one additional risk
blood in the brain (stroke) and other vessels of the body in patients with
It is used to prevent clot formation.
Blood in the veins in the legs (deep vein thrombosis) and in the lungs
treating blood clots in their veins (pulmonary embolism) and legs and / or
to prevent the recurrence of blood clots in the blood vessels in the lungs
2. Things to consider before using LIXIANA
DO NOT USE LIXIANA in the following situations
- Against Edoksaban or any substance in the composition of this drug (in section 6
listed) have allergies (hypersensitivity)
If you have excessive bleeding
- If you have a disease that increases the risk of serious bleeding in an organ in your body (stomach ulcer,
recent cerebral hemorrhage or injury, or recent
brain or eye surgery)
Other medicines to prevent blood clotting (e.g. warfarin, dabigatran, rivaroxaban,
apixaban or heparin) (your blood thinner treatment will be changed
conditions and heparin to keep the vein or capillary line open
- If you have a liver disease that increases the risk of bleeding
If you have uncontrollable high blood pressure
- If you are pregnant or breastfeeding
USE LIXIANA CAREFULLY in the following situations
Before using LIXIANA in the following situations, please contact your doctor or pharmacist.
- if you have an increased risk of bleeding and if you have any of the following conditions
if you have:
end-stage kidney disease or dependence on dialysis
severe liver disease
a problem with the blood vessels in the back of the eye (retinopathy)
recent cerebral hemorrhage (intracranial or intra-cerebral hemorrhage)
problems with blood vessels in the brain or spinal cord
You have a disease called antiphospholipid syndrome (which increases the risk of blood clots)
Tell your doctor if you know you have an immune system disease.
Your doctor will decide whether your treatment needs to be changed.
patients with mechanical heart valves
Lixiana 15 mg only Lixiana 30 mg to vitamin K antagonist drugs (eg.
warfarin) (See Section 3 How to use Lixiana?).
If you are going to have an operation:
You can use LIXIANA before and after the surgery at the time that your doctor has indicated.
it is very important that you use it. If possible, Lixiana at least 24 hours before surgery.
stop using it. Your doctor will tell you when to start using Lixiana again.
Using LIXIANA with food and drink
Lixiana with or without food, whole with some water
should be swallowed.
Consult your doctor or pharmacist before using this medication.
Do not use LIXIANA if you are pregnant or breastfeeding. If there is a possibility that you could become pregnant
If you are using Lixiana, you should use a reliable method of contraception. LIXIANA
If you become pregnant while using, consult your doctor immediately, your doctor will continue the treatment and
He will decide not to.
Vehicle and machine use
Lixiana has no effect on the ability to drive or use machines or has a negligible
has the effect.
Important information about some of the excipients in the content of LIXIANA
Lixiana contains trace amounts of mannitol. Dosage included in patients taking Lixiana
Therefore, it is not expected to have an effect related to mannitol.
Use with other medicines
If you are likely to use any medication, if you are currently using it or have
If you have used it at times, please inform your doctor or pharmacist.
If you are using any of the following medicines:
Some medicines for fungal infections (eg ketoconazole)
Medicines used to treat abnormal heartbeats (e.g. dronedarone,
Other medicines used to prevent blood clotting (e.g. heparin, clopidogrel or
vitamin K antagonists such as warfarin, acenocoumarol, phenprocoumon or dabigatran,
Antibiotic drugs (eg erythromycin)
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